ProT2® MHC Class II Tetramers

Kramer C. et al. (2020). “Generation and reactivity analysis of human recombinant monoclonal antibodies directed against epitopes on HLA-DR” AJT DOI: 10.1111/ajt.15950

Hartnell F. et al. (2020). Characterising HCV specific CD4+ T-cells following viral-vectored vaccination, directly acting anti-virals and spontaneous viral cure. https://doi.org/10.1002/hep.31160

Cianciotti B. et al. (2019). CD4+ memory stem T cells recognizing citrullinated epitopes are expanded in patients with rheumatoid arthritis and sensitive to tumor necrosis factor blockade. https://doi.org/10.1002/art.41157

Kramer C. et al. (2020). Generation and reactivity analysis of human recombinant monoclonal antibodies directed against epitopes on HLA-DR.  https://doi.org/10.1111/ajt.15950

Gliwinski M. et al. (2020). Proinsulin-specific T regulatory cell may control immune responses in type 1 diabetes: implications for adoptive therapy.  10.1136/bmjdrc-2019-000873

Pro5® MHC Class I Pentamers

Peng Y., Dong T., et al. (2020). Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients. Nature Immunology. DOI: 10.1038/s41590-020-0782-6

Ferdosi S. R. et. al. (2019). Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes. Nature Communications. DOI: 10.1038/s41467-019-09693-x

Chew G.M. et al. (2016). TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection. PLoS Pathog. DOI: 10.1371/journal.ppat.1005349

Magini D. et al. (2016). Self-Amplifying mRNA Vaccines Expressing Multiple Conserved Influenza Antigens Confer Protection against Homologous and Heterosubtypic Viral Challenge. PLoS One. DOI: 10.1371/journal.pone.0161193

Serafini B. et al. (2019). Epstein-Barr Virus-Specific CD8 T Cells Selectively Infiltrate the Brain in Multiple Sclerosis and Interact Locally with Virus-Infected Cells: Clue for a Virus-Driven Immunopathological Mechanism. J. Virology. DOI: 10.1128/JVI.00980-19

HLA Tissue Typing

Nyanhete T. E. et al. (2019). HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers. Scientific Reports. DOI: 10.1038/s41598-019-46462-8

Link J et al. (2014). Human Leukocyte Antigen Genes and Interferon Beta Preparations Influence Risk of Developing Neutralizing Anti-Drug Antibodies in Multiple Sclerosis. PLOS One DOI: 10.1371/journal.pone.0090479

Mahlangu, J.N. et al. (2015). Changes in the amino acid sequence of the recombinant human factor VIIa analog, vatreptacog alfa, are associated with clinical immunogenicity. Journal of Thrombosis and Haemostasis. DOI: 10.1111/jth.13141

Donnelly, RP. et al. (2011). Interferon-lambda and therapy for chronic hepatitis C virus infection. Trends in Immunology. DOI: 10.1016/j.it.2011.07.002

ProMap® T Cell Proliferation Assay

Mahlangu J. et al. (2016). TRUST trial: BAY 86-6150 use in haemophilia with inhibitors and assessment for immunogenicity. Haemophilia. DOI: 10.1111/hae.12994

O’Brien L.M. et al. (2012). A humanised murine monoclonal antibody protects mice from Venezuelan equine encephalitis virus, Everglades virus and Mucambo virus when administered up to 48h after airborne challenge. Virology. DOI: 10.1016/j.virol.2012.01.038

ProImmune REVEAL & ProVE® Epitope Discovery

Keller M.R. et al. (2013). Epitope Analysis of the Collagen Type V-Specific T Cell Response in Lung Transplantation Reveals an HLA-DRB1*15 Bias in Both Recipient and Donor. PLOS One. doi: 10.1371/journal.pone.0079601

Pandey G.S. et al. (2013). Polymorphisms in the F8 Gene and MHC-II Variants as Risk Factors for the Development of Inhibitory Anti-Factor VIII Antibodies during the Treatment of Hemophilia A: A Computational Assessment PLOS Computational Biology. doi: 10.1371/journal.pcbi.1003066

Milcent B., Siberil S. et al. (2019). Presence of T cells directed against CD20-derived peptides in healthy individuals and lymphoma patients. Scientific Reports. doi: 10.1007/s00262-019-02389-7

Westrop, S.J. et al. (2009). Novel approach to recognition of predicted HIV-1 Gag B3501-restricted CD8 T-cell epitopes by HLA-B3501(+) patients: confirmation by quantitative ELISpot analyses and characterisation using multimers. J Immunol Methods. doi: 10.1016/j.jim.2008.11.003.

Steinitz, K. et al. (2012). CD4+ T-cell epitopes associated with antibody responses after intravenously and subcutaneously applied human FVIII in humanized hemophilic E17 HLA-DRB1*1501 mice. Blood. doi: 10.1182/blood-2011-08-374645

ProScern® DC-T Cell Assay

Jambari, N. et al (2021) Effect of O-linked glycosylation on the antigenicity, cellular uptake and trafficking in dendritic cells of recombinant Ber e 1. PLoS One 16: 10.1371/journal.pone.0249876 [PubMedID: 33914740]

Steven, J. et al (2017) In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development. Frontiers in Immunology. [PubMedID: 29109729]

B cell Epitope Discovery Services

B cell Epitope Discovery Services

ELISPOT Assay

ELISPOT Assay

ProPresent® Antigen Presentation Assay

ProPresent® Antigen Presentation Assay

ProMix™ Peptide Pools

ProMix™ Peptide Pools

PEPscreen® Peptide Libraries

PEPscreen® Peptide Libraries

ProImmune Peptides

ProImmune Peptides

CD1d Tetramers

Engkilde, K. et al. (2010). Prevention of diabetes in NOD mice by repeated exposures to a contact allergen inducing a sub-clinical dermatitis. PLoS One. DOI: 10.1371/journal.pone.0010591

Nur, H. et al. (2013). Preclinical Evaluation of Invariant Natural Killer T Cells in the 5T33 Multiple Myeloma Model. PLoS ONE. DOI: 10.1371/journal.pone.0065075

Barral, P. et al. (2012). The location of splenic NKT cells favours their rapid activation by blood-borne antigen. The EMBO Journal. DOI: 10.1038/emboj.2012.87

Barral, P. et al. (2010). CD169+ Macrophages present lipid antigens to mediated early activation of invariant NKT cells in lymph nodes. Nature Immunology. DOI: 10.1038/ni.1853

Model Antigens

Diallo J.S. et al. (2020). Oncolytic Rhabdovirus Vaccine Boosts Chimeric Anti-DEC205 Priming for Effective Cancer Immunotherapy. Molecular Therapy Oncolytics. doi: 10.1016/j.omto.2020.10.007

Arnaboldi P.M. et al. (2009). Suppression of Th1 and Th17, but not Th2, responses in a CD8+ T cell-mediated model of oral tolerance. Mucosal Immunology. doi: 10.1038/mi.2009.93

Adriouch S. et al. (2011) Improved Immunological Tolerance Following Combination Therapy with CTLA-4/Ig and AAV-Mediated PD-L1/2 Muscle Gene Transfer. Frontiers in Microbiology. doi: 10.3389/fmicb.2011.00199

Other

Other

Vaccinia Virus

Vaccinia Virus

Trypanosoma Cruzi

Trypanosoma Cruzi

Respiratory Syncytial Virus (RSV)

Respiratory Syncytial Virus (RSV)

Mycobacterium Tuberculosis

Mycobacterium Tuberculosis

Minor Histocompatibility Antigen (miHAg)

Minor Histocompatibility Antigen (miHAg)

Malaria

Malaria

Listeria

Husseiny MI. and Hensel M. et al. (2009). Evaluation of Salmonella live vaccines with chromosomal expression cassettes for translocated fusion proteins. Vaccine. DOI: 10.1016/j.vaccine.2009.03.053

Gurung P. et al. (2009). Chronic ethanol induces inhibition of antigen-specific CD8+ but not CD4+immunodominant T cell responses following Listeria monocytogenes inoculation. J. Leukoc. Biol. DOI: 10.1189/jlb.0208101

Lee S.M. et al. (2009). Expression and Function of TLR2 on CD4 Versus CD8 T Cells. Immune Network. DOI: 10.4110/in.2009.9.4.127

Edelson B.T. et al. (2011). CD8α+ Dendritic Cells Are an Obligate Cellular Entry Point for Productive Infection by Listeria monocytogenes. Immunity. DOI: 10.1016/j.immuni.2011.06.012

Lymphocytic Choriomeningitis Virus (LCMV)

Lymphocytic Choriomeningitis Virus (LCMV)

Influenza

InfluenzaInfluenza

Human Papillomavirus (HPV)

Human Papillomavirus (HPV)

Human T-lymphotropic Virus (HTLV)

Human T-lymphotropic Virus (HTLV)

Human Immunodeficiency Virus (HIV)

Human Immunodeficiency Virus (HIV)Human Immunodeficiency Virus (HIV)

Human Herpes Virus (HHV/HSV)

Human Herpes Virus (HHV/HSV) Description

Hepatitis C (HCV)

Hepatitis C (HCV) Description

Hepatitis B (HBV)

Hepatitis B (HBV) Description

Epstein-Barr Virus (EBV)

Epstein-Barr Virus (EBV) Description

Cytomegalovirus (CMV)

Cytomegalovirus (CMV) Description

Chlamydia

Chlamydia Description

Cancer

Cancer Description

Adenovirus

Adenovirus Description

Autoimmunity

Autoimmunity Description

Allergy

Allergy Description